ABSORPTION AND METABOLISM OF HYDROCORTISONE-4-C14

Absorption and metabolism of cortisone-4-C14 acetate.

Previous work in this laboratory with steroids labeled with Cl4 (l-10) has been extended to include the present experiments on the absorption and disposition of the radioactive carbon of cortisone-4-U4 acetate’ in the rat. Since the conditions of these experiments, i.e. solvent vehicle, strain and type of animal studied, operative techniques, method of collection of specimens, and Cl4 assay, di...

Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14.

It has become increasingly apparent in recent years that certain structural alterations of corticosteroids cause an increased biological potency of the resultant steroid (2). A number of chemical and microbiological alteration products of hydrocortisone exhibit enhanced anti-inflammatory potency coupled with unchanged or depressed mineralocorticoid activity (2, 3). As a result, steroids bearing...

Metabolism of Coprostanol-c14 and Cholestanol-4-c14 in Man.

Metabolic transformation of hydrocortisone-4-C14 in normal men.

The fate of hydrocortisone in man has been extensively studied (l-7) but the quantitative aspects of the transformation to its many metabolites in individual normal subjects leave much to be desired (8-16). This study reports the metabolism of an intravenous dose of hydrocortisone-4-Cl4 in five normal male subjects and of an oral dose in one of these subjects. The metabolites” cortol, /I-cortol...

Metabolism of epicholesterol-4-C14 in the rat.

Recent studies on the catabolism of cholesterol-4-Cl4 in the rat have shown that the isot,opic carbon is eliminated from the body almost entirely with the feces and that up to 90 per cent of the fecal Cl4 enters the intestine via the bile. Not more than 10 per cent of the Cl4 is excreted directly through the intestinal wall. Approximately 90 per cent of the Cl4 recovered in bile is in the form ...